Murphy, S. A. "An experimental design for the development of adaptive treatment strategies." Statistics in Medicine. 24 (2004): 1455-1481
Adaptive treatment strategies use similar ideas as adaptive experimental design. Using experimental trials to develop the decisions in the assigned treatments helps researchers to more quickly discover the optimal treatment schedule for long-term disorders such as hypertension, alcoholism, depression, etc. In addition to making decisions, this article discusses a major challenge in the field, that of delayed effects.
"The rationale is that the response is optimized by varying treatment type and dosage as a function of measures of time dependent information." This paper helps me understand different aspects of adaptive experimental design. Because I am unfamiliar with the idea of experimental designs, it is useful for me to learn about various facets of the field, such as the delayed effects challenge.
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